. 2019 Jul 8;6(7):ofz277. doi: 10.1093/ofid/ofz277

Table 1.

Central Nervous System Penetration Effectiveness Scores for Antiretroviral Agents Used to Date

0	1	2	3	4
Amprenavir	Tenofovir disoproxil fumarate	Didanosine	Abacavir	Zidovudine
Amprenavir/r	Tenofovir alafenamide^a	Lamivudine	Emtricitabin	Nevirapine
Cobicistat	Zalcitabine	Stavudine	Efavirenz	Dolutegravir^a
	Enfuvirtide	Etravirine	Delavirdine	Indinavir/r
	Ritonavir^b	Rilpivirine^a	Raltegravir
	Saquinavir	Elvitegravir^a	Maraviroc
	Saquinavir/r	Fos-amprenavir	Fos-amprenavir/r
	Tipranavir/r	Atazanavir	Indinavir
	Nelfinavir	Atazanavir/r	Lopinavir/r
			Darunavir/r

NOTE: Adapted from Letendre et al [18] with permission.

^aLetendre et al [35] with permission and personal communication from Dr. Scott Letendre (unpublished data), written communication (22 June 2018).

^bWhen used as a nonbooster.