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. 2019 Jan 7;9:2235042X18820209. doi: 10.1177/2235042X18820209

Table 3.

Impact of the comorbidity COPD-RDs on patients outcomes.

First author Publication year Country Design Sample Main outcomes
Hyldgaard et al.30 2018 Denmark Population-based 31,333 patients with RA (10.4% of them with COPD) versus 9,706 RA patients without COPD Mortality risk in RA patients with COPD versus RA patients without COPD: aHRR = 3.0 (95% CI: 2.3–3.9) and aHRR = 2.1 (95% CI: 1.9–2.1) in 0–6 months and in first 10 years after RA diagnosis
McGuire et al.35 2017 British Columbia Retrospective cohort 24,625 patients with RA versus 25,396 controls Risk of COPD hospitalization in RA patients: IRR 1.47 (95% CI: 1.24–1.74)
Pieringer et al.36 2017 Austria Cross-sectional 74 patients with RA versus 74 controls Association of COPD/RA with ICU admission: OR 2.89 (95% CI: 1.10–7.54; p = 0.03)
Han and Han43 2017 United States Registry-based 1,680 total visits with SLE COPD leads to 6.9% of hospitalizations in male and 3.7% in female SLE patients >60 years
Nannini et al.22 2013 Rochester, Minnesota Population-based cohort 594 patients with RA versus 596 controls Worse survival in RA with COPD or asthma versus without respiratory comorbidities: HR 2.09 (95% CI: 1.47–2.97), adjusted for age, sex, smoking, and alcohol

COPD: chronic obstructive pulmonary disease; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; aHRR: adjusted hazard rate ratio; HR: hazard ratio; ICU: intensive care unit; IRR: incidence rate ratio; OR: odds ratio; CI: confidence interval.