Table 3.
First author | Publication year | Country | Design | Sample | Main outcomes |
---|---|---|---|---|---|
Hyldgaard et al.30 | 2018 | Denmark | Population-based | 31,333 patients with RA (10.4% of them with COPD) versus 9,706 RA patients without COPD | Mortality risk in RA patients with COPD versus RA patients without COPD: aHRR = 3.0 (95% CI: 2.3–3.9) and aHRR = 2.1 (95% CI: 1.9–2.1) in 0–6 months and in first 10 years after RA diagnosis |
McGuire et al.35 | 2017 | British Columbia | Retrospective cohort | 24,625 patients with RA versus 25,396 controls | Risk of COPD hospitalization in RA patients: IRR 1.47 (95% CI: 1.24–1.74) |
Pieringer et al.36 | 2017 | Austria | Cross-sectional | 74 patients with RA versus 74 controls | Association of COPD/RA with ICU admission: OR 2.89 (95% CI: 1.10–7.54; p = 0.03) |
Han and Han43 | 2017 | United States | Registry-based | 1,680 total visits with SLE | COPD leads to 6.9% of hospitalizations in male and 3.7% in female SLE patients >60 years |
Nannini et al.22 | 2013 | Rochester, Minnesota | Population-based cohort | 594 patients with RA versus 596 controls | Worse survival in RA with COPD or asthma versus without respiratory comorbidities: HR 2.09 (95% CI: 1.47–2.97), adjusted for age, sex, smoking, and alcohol |
COPD: chronic obstructive pulmonary disease; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; aHRR: adjusted hazard rate ratio; HR: hazard ratio; ICU: intensive care unit; IRR: incidence rate ratio; OR: odds ratio; CI: confidence interval.