Fig. 2.
Forelimb overuse increases long-term survival and neuronal differentiation of SVZ-derived progeny into the peri-infarct cortex 60 d after stroke. (A) Confocal micrographs of tdTomato+ and NeuN+ cells in the peri-infarct cortex of the Ascl1–CreERT2::tdTomato mice 60 d after stroke. Arrowheads, tdTomato+NeuN+ cells. (Scale bar: 5 µm.) (B) Quantification of density of tdTomato+, tdTomato+NeuN+, and tdTomato+DCX+ cells in the peri-infarct region. (C) Confocal micrographs of tdTomato+ and DCX+ cells in the peri-infarct cortex of the Ascl1–CreERT2::tdTomato mice 60 d after stroke. Arrowheads: tdTomato+DCX+ cells. (Scale bar: 5 µm.) (D) Percentages of tdTomato cells that coexpress NeuN and DCX in the peri-infarct region. *P < 0.05.