Fig. 3.

Effects of cerebellar GABAergic dysfunctions on tremor-related neural oscillations in the CCTC model. (A) Two-dimensional map depicting the region of the parameter space (R, τ^PC→DCN) where tremor activity in the Vim is observed along with the tremor peak frequency. The blue mark indicates parameters used to simulate normal, tremor-free conditions. The yellow circle indicates parameters used for the ET-like tremor activity analyzed in B and E, i.e., R = 0.7, τ^PC→DCN = 12 ms. For each combination of parameters (R, τ^PC→DCN), the CCTC model was simulated for 4,000 ms, and the first 1,000 ms were excluded from subsequent analyses. (B–E) Comparison between the bursting activity of DCN under harmaline-induced tremor (HAR; black bars) and GABAergic dysfunctions of the PC-DCN synapses (ET; gray bars). The burst analysis was performed as reported in SI Appendix, Note 2, on data collected over 60,000-ms-long simulations. The average burst period (B), burst duration (C), interburst interval (D), and intraburst discharge rate (E) are reported as mean ± SD across three model instances. Asterisks denote significant difference (Wilcoxon rank-sum test, P < 0.01) between values measured under HAR and ET conditions.