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. 2019 Jun 28;13:993–1004. doi: 10.2147/PPA.S205359

Table 4.

Top three reasons for non-adherence with medicines taken daily and orally across all the 17 disease conditions

Disease conditiona Sample size 1st reason 2nd reason 3rd reason
Diabetes 2,746 Simply missed it (11.4%) Busy schedule (6.4%) Side effects (5.6%)
Arthritis 2,480 Long-term effects (12.7%) Skip to see if medicine is still needed (12.0%) Simply missed it (11.9%)
IBD 254 Side effects (20.9%) Simply missed it (20.5%) Long-term effects (19.3%)
GERD/Heartburn 4,442 Simply missed it (13.1%) Skip to see if still needed (11.1%) Long-term effects (8.0%)
Chronic constipation 393 Skip to see if still needed (19.1%) Simply missed it (16.5%) Long-term effects (14%)
IBS 659 Skip to see if it is still needed (15.0%) Simply missed it (14.6%) Long-term effects (11.7%)
Psoriasis 137 Side effects (44.5%) Long-term effects (38.0%) Skip to see if still needed (36.5%)
Eczema 171 Side effects (39.2%) Long-term effects/Skip to see if still needed (35.1%) Simply missed it (33.3%)
Lupus 119 Long-term effects (21.0%) Possible side effects (19.3%) Side effects/Simply missed it (17.7%)
Multiple sclerosis 89 Simply missed it/Side effects (14.6%) Long-term effects/Medicine not working (12.4%) Personal Reasons/Cost (11.2%)
Epilepsy 294 Simply missed it (14.3%) Side effects (12.6%) Long-term effects/Possible side effects (11.2%)
Sleep condition 2,812 Skip to see if still needed (14.9%) Simply missed it (13.6%) Side effects (13.1%)
Depression 4,798 Simply missed it (16.4%) Side effects (9.5%) Busy schedule (9.1%)
Migraine 1,055 Side effects (16.6%) Skip to see if it is still needed/Long term effects (16.4%) Possible side effects (15.0%)
Pain 4,056 Skip to see if still needed (13.1%) Long-term effects (12.1%) Simply missed it (11.6%)
Osteoporosis 307 Simply missed it (17.0%) Possible side effects (13.7%) Long-term effects (13.0%)
Overactive bladder 953 Simply missed it (15.5%) Side effects (12.5%) Skip to see if still needed (12.0%)

Notes: aEczema = Eczema/Atopic Dermatitis/Dermatitis; Sleep condition = Sleep difficulties/Insomnia/Narcolepsy/Sleep Apnea; Pain = Pain/Fibromyalgia/Diabetic Neuropathic Pain; Overactive bladder = Wet/Dry/Stress Urinary Incontinence; Osteoporosis = Osteoporosis/Osteopenia; Arthritis = Rheumatoid Arthritis/Psoriatic Arthritis/Osteoarthritis/Ankylosing Spondylitis; Diabetes = Type 1/Type 2/Latent Autoimmune Diabetes in Adults.

Abbreviations: GERD, GastroEsophageal Reflux Disease; IBD, Inflammatory Bowel Disease; IBS, irritable bowel syndrome.