Table 2.

Pharmacokinetics of ceftolozane–tazobactam in healthy adults^38,39

Antibiotic (1 g ceftolozane – 0.5 g tazobactam)	Ceftolozane	Tazobactam
Cmax mg/dl	58–92	18.0–18.4
Plasma half-life (h)	1.86−2.64	1.0–1.1
Protein binding (%)	16–21	30%
AUC (mg h/L)	143–230	24–25
Volume of distribution (L)	13–17	18.2
Epithelial lining fluid (ELF) (%)	0.46–0.60	44–46
ELF (mean mg/dL)	21	8
Urinary elimination (%)	97−100	>80%
Hemodialysis removal	>90%	-

Notes: Adapted from: Miller B, Hershberger E, Benziger D, Trinh M, Friedland I. Pharmacokinetics and safety of intravenous ceftolozane-tazobactam in healthy adult subjects following single and multiple ascending doses. Antimicrob Agents Chemother. 2012;56(6):3086–3091. Copyright © 2012, American Society for Microbiology. All Rights Reserved.³⁸ And from: Ge Y, Whitehouse MJ, Friedland I, Talbot GH. Pharmacokinetics and safety of CXA-101, a new antipseudomonal cephalosporin, in healthy adult male and female subjects receiving single and multiple-dose intravenous infusions. Antimicrob Agents Chemother. 2010;54(8):3427–3431. Copyright © 2010, American Society for Microbiology.³⁹