Table 3.
Clinical characteristics and outcome of patients treated with ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosa intra-abdominal infections
| Age/sex (reference) | Comorbidities | Type of infection | Procedure | Presence of bacteremia | Initial presentation of infection | Duration, dose of C/T treatment | Creatinine clearance mL/min) | Other anti-pseudomonal agents given in combination with CT | Clinical outcome (days) | Microbiological outcome | CT MIC (μg/mL, initial → subsequent) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 65/F61 | Diabetes | Abdominal | Drainage of abscess | Yes | Septic shock | 14 days, 1.5 g q8h | No data | No data | Cure | Eradication | 0.25 |
| 70/M61 | None | Intrabdominal infection | Drainage of abscess | No | Septic shock | 21 days, 1.5 g q8h | No data | No data | Cure | Eradication | 0.5 |
| 53/M61 | Hepatitis C infection | Intrabdominal infection | Laparotomy | No | Septic shock | 11 days, 1.5 g q8h | No data | No data | Death | Persistence | <4 |
| 76/F61 | Diabetes mellitus, COPD | Biliary infection | Biliary drainage | No | Septic shock | 9 days, 1.5 gq8h | No data | No data | Cure | Eradication, late colonization with resistant isolate | 1 → 48 |
| 58/F62 | Pancreatitis, ventilator-dependent respiratory failure | Intrabdominal infection | No data | No data | SAPS II 26, SOFA Score 8 | 40 days, 750 mg q8h | 15–29 | Inhaled colistin | Cure | Colonization with resistant isolate during treatment | 4 → 128 |
| 54/M63 | Acute myeloid leukemia | Perirectal abscess | No data | No data | No data | 21 days, 3 g q8h | >70 | No | Cure | Eradication | 1.5 |
| 70/M63 | Liver transplantation | Liver abscess | No data | No data | No data | 28 days, 1.5 g q8h | >50 | No | Cure | Eradication | 0.75 |
| 71/F63 | Uterine malignancy | Pelvic abscess | No data | No data | No data | 7 days, 750 mg q8h | 30–50 | IV ciprofloxacin | Death | Eradication | 2 |
| 48/F64 | Pancreatic cancer | Intrabdominal infection | No data | No data | No data | 16 days, 3 g q8h | 69 | No | Cure | No data | No data |
| 53/F64 | Autoimmune hepatitis | Intraabdominal infection | No data | No data | No data | 15 days, 1.5 g q8h | 19 | No | Death | No data | No data |
| 74/M65 | Liver cirrhosis, recent subtotal colectomy, chemotherapy and resection of hepatic metastases | Hepatic abscess secondary to biliary leakage | Percutaneous drainage | No | No data | 6 weeks, 1.5 g q8h | 46 | IV colistin | Cure | No data | 3 |
| 44/M65 | Liver transplantation due to sclerosing cholangitis | Cholangitis | No | Yes | Septic shock | 4 weeks, 1.5 g q8h | >90 | No | Cure | Eradication | 1 |
| 54/F65 | Gastrectomy for gastric carcinoma, with suture leakage, needing surgical reintervention | Abdominal abscess | Percutaneous drainage | No | No data | 9 days, 1.5 g q8h | >90 | No | Cure | No data | 1.5 |