. 2019 Jul 1;9:55–78. doi: 10.2147/DNND.S208815

Table 7.

Intravenous methylprednisolone followed by oral prednisone taper, either alone or concomitant with PMP or IA

Study/N/Age/Location	Intervention and treatment duration	Summary of efficacy results
Schmitt et al (1990)³³ N=17 Age: NR Germany	Intervention IVMP vs IVMP and PMP vs IVMP and IAIVMP in each arm followed by OPT); all n= NR Treatment duration IVMP: 1 week OPT: 4 weeks PMP: 1 week IA: 1 week Assessments Prior to study entry as well as 2 weeks, 3 months, and 1 year after baseline	EDSS scores^a IVMP (followed by OPT): Baseline: ~4.9 2 weeks: ~4.4 3 months: ~5 1 year: ~6.2 IVMP (followed by OPT) and PMP: Baseline: ~5 2 weeks: ~4.2 3 months: ~3.8 1 year: ~4.5 IVMP (followed by OPT) and IA: Baseline: ~5.4 2 weeks: ~3.8 2 months: ~3.3 1 year: ~5.3

Note: The dose used in this study was 60 mg/day for one week, followed by 30 mg oral CS for 4 weeks. This is below the accepted dose of 500 mg to 1 g per day. ^aEstimated from figure; actual values not reported.

Abbreviations: EDSS, Expanded Disability Status Scale; IA, immunoadsorption; IVMP, intravenous methylprednisolone; NR, not reported; OPT, oral prednisone taper; PMP, plasmapheresis; RCT, randomized controlled trial.