Table 12.

Repository corticotropin injection

Study/N/Age/Location	Intervention and treatment duration	Summary of efficacy results
National Cooperative Clinical Trial Henderson et al (1978)45 Rose et al (1969)46 Rose et al (1970)47 N=197 Age: NR US	Intervention RCI IM (n=103) vs placebo (n=94) Treatment duration 14 days Assessments Within 24 hrs of treatment onset, days 7 and 14 of treatment, and days 7 and 14 following treatment	Proportion of patients improved DSS score (≥1 score change) at week 1 after treatment initiation: RCI, 38%; placebo, 26% DSS at week 2: RCI, 57%; placebo, 38% DSS at week 3: RCI, 61%; placebo, 49% DSS at week 4: RCI, 65%; placebo, 48%
Simsarian et al (2011)48 N=20 Age: 39.5 US	Intervention RCI SC (n=10) vs RCI IM (both self-administered) (n=10) Treatment duration 5 days Assessments Baseline, days 7 and 14	Mean EDSS scores at baseline: IM, 2.30; SC, 2.80; all, 2.55 Mean EDSS score on day 7±1 day: IM, 1.20; SC, 2.65; all, 1.93 Mean EDSS scores on day 14±1 day: IM, 1.10; SC, 2.89; all, 1.95

Abbreviations: DSS, Disability Status Scale; EDSS, Expanded Disability Status Scale; IM, intramuscular; NR, not reported; RCI, repository corticotropin injection; RCT, randomized controlled trial; SC, subcutaneous; US, United States.