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. 2019 Jul 8;15(7):e8838. doi: 10.15252/msb.20198838

Figure 5. An adaptive chronotherapeutic approach identifies the precise dosing regimen.

Figure 5

  • A
    By tracking the patients’ heterogeneous drug response caused by different genetics and environments, adaptive chronotherapeutics adjusts the dosing time: If the current dosing regimen leads to a weaker or stronger drug effect than the desired one, the dosing time is delayed or advanced by 1 h, respectively (see Fig EV6A for details).
  • B, C
    By adjusting the initial dosing time (ZT3) according to the adaptive chronotherapeutics, the precise dosing time can be obtained for each ASPD model (colored number; B), with which a single daily 10 mpk dosing leads to the desired ˜4‐h phase delay in LD 16:8 (gray range; C).
  • D, E
    When day length decreases to 8 h (LD 8:16), the precise dosing times are considerably advanced.