Table 3.

Relationship between lesional H scores of JAK1 and STAT3 with demographic and clinical parameters

Parameters	JAK1 H score in epidermis	STAT3 H score in epidermis	Test	P-value
Mean ± SD	Mean ± SD
Gender
Male	164.3±21.2	241.1±40.8	t1 test=0.14	P1=0.88
Female	165.7±19.8	188.7±21.01	t2 test=3.4	P2=0.002*
Stability
Stable	170±`4.5	211.9±35.1	U =2.61	P1=0.01*
Progressive	146±28.8	280±29.1	t2 test=4.01	P1=0.01*
Disease severity
Mild	160±2.1	170	F1=1.7	P1=0.27
Moderate	178±14.8	178±14.8	F2=11.4	P2=0.001*
Severe	161.1±21.1	243.1±35.7
	JAK1 H score in dermis	STAT 3 H score in dermis
Mean ± SD	Mean ± SD
Gender:
Male	168.3±11.9	199.2±44.8	t1 test=3.04	P1=0.007*
Female	145.7±20.7	178±24.9	t2 test=0.99	P2=0.33
Stability
Stable	160±1.3	182.8±29.7	t1 test=0.09	P1=0.11
Progressive	160.3±1.5	253.3±46.1	t2 test=3.50	P2=0.003*
Disease severity
Mild	120±1.3	220	F1 test=5.8	P1=0.01*
Moderate	151.6±19.4	158±22.8	F2 test=3.30	P2=0.06
Severe	167.5±12.8	205.3±40.1

Notes: *, significant; P₁, p-value in JAK1; P₂, p-value in STAT3; t1, student t-test in JAK1; t2, student t-test in STAT3; F1, ANOVA test in JAK1; F2, ANOVA test in STAT3; U, Mann–Whitney test.

Abbreviations: JAK1, janus kinase 1; STAT3, signal transducer and activator of transcription.