Table 1.
Functional characterization of SNHG15 in various cancers
| Cancer types | Expression | Functional roles | Related genes | Role | References |
|---|---|---|---|---|---|
| Breast cancer | Upregulated | Proliferation, migration, invasion, cell cycle arrest, apoptosis, EMT | MiR-211-3p, E-cadherin, vimentin, MMP2, MMP9, SNAI1 | Oncogenic | 21 |
| Colorectal cancer | Upregulated | Migration, EMT, tumor growth | Slug, E-cadherin | Oncogenic | 22,23 |
| Gastric cancer | Upregulated | Proliferation, migration, invasion, apoptosis, tumorigenesis | MMP2, MMP9 | Oncogenic | 20 |
| Glioma | Upregulated | Proliferation, migration, angiogenesis | MiR-153, VEGFA, Cdc42 | Oncogenic | 24 |
| Lung cancer | Upregulated | Proliferation, migration, invasion, cell cycle arrest, apoptosis, EMT | MiR-486, miRNA-211-3p, CDK14, BAX, Bcl-2, cleaved caspase-3, PARP, E-cadherin, N-cadherin, Vimentin, MMP-2, MMP-9 | Oncogenic | 26–28 |
| Osteosarcoma | Upregulated | Proliferation, migration, invasion, autophagy | MiR-141, Atg5, LC3-II, p62 | Oncogenic | 29 |
| Epithelial ovarian cancer | Upregulated | Proliferation, migration, invasion, drug resistance | — | Oncogenic | 30 |
| Pancreatic cancer | Upregulated | Proliferation, apoptosis, cell cycle arrest, tumorigenesis | EZH2, H3K27me3, P15, KLF2, CDK2, CDK4, cleaved caspase-3, cleaved caspase-9 | Oncogenic | 31,32 |
| Renal cell cancer | Upregulated | Proliferation, migration, invasion, cell cycle arrest, apoptosis, EMT | TNF-α, Snail1, Slug, ZEB1, E-cadherin, N-cadherin, Vimentin | Oncogenic | 33 |
| Thyroid cancer | Upregulated | Proliferation, migration, apoptosis, EMT | MiR-200a-3p, YAP1, MST1, LATS1, E-cadherin, N-cadherin, Vimentin, β-catenin | Oncogenic | 34 |
| Downregulated | Proliferation, migration, invasion | MiR-510-5p | Nononcogenic | 35,36 |
Abbreviations: EMT, Epithelial to mesenchymal transition; MMP, matrix metalloproteinase; SNAI1, snail family transcriptional repressor 1; VEGFA, vascular endothelial growth factor A; CDK, cyclin-dependent kinase; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; PARP, poly(ADP-ribose) polymerase; EZH2, enhancer of zeste homolog 2.