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. 2019 Jun 25;27(13):3725–3732.e5. doi: 10.1016/j.celrep.2019.05.098

Figure 1.

Figure 1

A Subpopulation of PVIs in the dDG Expresses Variable and Input-Specific Densities of Dendritic Spines

(A) AAV-FLEX-GFP was injected into the dDG of PV-Cre mice. Co-localization of GFP (green) and PV (red) was confirmed by immunohistochemistry. Example images of transduced non-spiny (top) and spiny (bottom) apical dendrites of PVIs are shown alongside confocal gray-scale magnifications of boxed areas. Roman numbers link boxed areas to matching magnifications. Arrowheads indicate examples of spines.

(B) Example of spines on basal PVI dendrites with a gray scale magnification of the boxed area.

(C) Spine densities of individual apical dendritic segments show high variability (n = 248 segments, 37 neurons, 3 mice; bars are mean ± SD).

(D) Apical spine densities decrease from inner to outer ml (n = 60 neurons, 6 mice; bars are mean ± SEM). Right, images i, ii, and iii show higher magnifications of a typical spiny PVI dendrite crossing the ml sublayers (bottom).