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. 2019 Jun 19;11(26):22932–22940. doi: 10.1021/acsami.9b04663

Figure 4.

Figure 4

Schematic illustration of two synthetic approaches toward hRNF functionalization: (i) in situ introducing modified uridine triphosphates (UTP) (i.e., biotin-UTP and DBCO-UTP) during the RCT reaction and (iia, iib) electrostatically adsorbing positively charged proteins (i.e., avidin) onto the as-synthesized hRNFs to which biotinylated cargos can bind via biotin–avidin recognition. Biotin- or DBCO-conjugated UTP (Bio-UTP or DBCO-UTP); biotin-, DBCO-, or avidin-modified hRNFs (Bio-hRNFs, DBCO-hRNFs, or Av-hRNFs).