Fig. 1.

Hypoleptinemia-mediated hypercorticosteronemia causes hyperphagia in fasted and type 1 diabetic rats. (A and B) Plasma leptin and corticosterone in healthy rats after 4 h of infusion, before refeeding. (C) Food intake measured over a 2-h period. (D and E) Plasma leptin and corticosterone in healthy and type 1 diabetic rats after 4 h of infusion, before refeeding. (F) Food intake measured over 2 h. In all panels, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 by one-way ANOVA with Bonferroni’s multiple-comparisons test. Data are the mean ± SEM.