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. 2019 Jun 18;116(27):13670–13679. doi: 10.1073/pnas.1901795116

Fig. 3.

Fig. 3.

Elevated leptin abrogates HPA axis-mediated hyperphagia. (A and B) Plasma leptin and corticosterone in chow-fed rats. (C) Food intake after 48-h food withdrawal. (D–F) Plasma leptin and corticosterone and refed food intake in 2-wk HFD rats. (G and H) Plasma leptin and corticosterone in HFD rats before and after a VLCD to normalize body weight. (I) Food intake. In all panels, *P < 0.05, **P < 0.01, and ***P < 0.001 between the groups designated or, in the case of symbols over individual bars, versus the same group, fed. +P < 0.05, ++P < 0.01, and +++P < 0.001 versus the same group, fasted. In all panels, different groups were compared by one-way ANOVA with Bonferroni’s multiple-comparisons test, while the same group was compared at different feeding time points by paired ANOVA (A–F) while HFD vs. HFD-VLCD rats were compared at the same fasting time point by paired t test. Data are the mean ± SEM of n = 8 per group.