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. 2019 Jul 3;12:5269–5279. doi: 10.2147/OTT.S201025

Figure 1.

Figure 1

H. pylori enhances migration and invasion of gastric cancer cells in Ca2+-dependent manner. AGS and MKN45 cells were preincubated with calcium chelator, BAPTA-AM, and then incubated with H. pylori for 24 hrs. (A) Scratch wounding assay was performed to evaluate the migration of GC cells in response to H. pylori infection and BAPTA-AM treatment, respectively. (B) Representative images and micrographs of the transwell matrix penetration assay showing the H. pylori-induced invasiveness of GC cells pretreated with BAPATA-AM or DMSO. Data shown in the histogram are summary of three independent experiments;  *P<0.05 and ** P<0.01.