Figure 6.

H. pylori infection was associated with increased expression of TRPC6 in GC tissues and poor prognosis of GC patients. (A) The relative mRNA expression of TRPC6 in gastric cancer tissues from H. pylori-positive (n=30) and H. pylori-negative (n=22) patients. (B) Representative immunohistochemical staining for TRPC6 in gastric cancer tissues from H. pylori-positive (n=159) and H. pylori-negative (n=201) patients. Right panel: TRPC6 expression levels were scored with semi-quantitative immunohistochemical analysis. (C) Kaplan–Meier curves comparing overall survival in GC patients with positive and negative infection of H. pylori (n=360; P<0.0001). (D) Schematic model of H. pylori-induced TRPC6/Ca²⁺ signaling through activation of the Wnt/β-catenin signaling pathway, which promotes migration and invasion of human gastric cancer cells.