Table 3.
Comparison of melatonin and cortisol levels with increasing number of phenotypic features of the Rotterdam criteria
| Number of PCOS features | N | Mean ±SD | Unadjusted mean difference | 95% CI | Adjusteda mean difference | 95% CI |
|---|---|---|---|---|---|---|
| Melatonin | ||||||
| 0 out of 3 | 122 | 37.5 ± 26.1 | ‐ | ‐ | ‐ | ‐ |
| 1 out of 3 | 90 | 41.7 ± 28.5 | 4.11 | ‐3.59, 11.8 | 2.42 | ‐5.73, 10.6 |
| 2 out of 3 | 68 | 44.4 ± 26.0 | 6.87 | ‐1.52, 15.3 | 3.32 | ‐5.65, 12.3 |
| 3 out of 3 | 41 | 56.0 ± 35.9 | 18.4 | 8.43, 28.4 | 16.0 | 4.85, 27.2 |
| P‐trend: <0.001 | ||||||
| Cortisol | ||||||
| 0 out of 3 | 122 | 103 ± 35 | ‐ | ‐ | ||
| 1 out of 3 | 90 | 107 ± 40 | 3.49 | ‐7.21, 14.2 | 0.784 | ‐10.3, 11.9 |
| 2 out of 3 | 68 | 108 ± 44 | 4.86 | ‐6.79, 16.5 | ‐0.174 | ‐12.4, 12.0 |
| 3 out of 3 | 41 | 125 ± 39 | 21.2 | 7.36, 35.1 | 17.5 | 2.27, 32.6 |
| P‐trend: 0.003 | ||||||
a
Adjusted for age, BMI, education, medical history of depression, anxiety, stress or sleep disorders, shift work, sleep duration, exercise frequency, smoking, alcohol consumption, coffee consumption and self‐perceived stress levels.