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. 2019 Jul 8;20:133. doi: 10.1186/s13059-019-1749-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Enrichment of blood pressure (BP) and coronary artery disease (CAD)-associated SNPs in open chromatin regions. We compared overlap in endothelial cells (teloHAEC) and all available tissues from ENCODE. Each biological replicate is identified by a different point. We called all ATACseq peaks with the same bioinformatic pipeline. To account for the different coverage of each ATACseq library, we present the relative fraction of ATACseq peak that overlap with a BP or CAD SNP. We used body mass index (BMI)-associated SNPs as controls, since BMI is not a vascular phenotype. The gray box highlights results generated in this study in non-treated (NT) or TNFα-stimulated (4 or 24 h) teloHAEC