Table 1. Demographic and Clinical Characteristics of Men Aged 66 Years and Older Diagnosed With Prostate Cancer Between 1996 and 2003, According to ADT Status.
| Variable | Unadjusted | Propensity Score–Adjusteda | ||||
|---|---|---|---|---|---|---|
| No ADT, No. (%) (n = 91 759) | ADT, No. (%) (n = 62 330) | P Value | No ADT, No. (%) (n = 93 238)b | ADT, No. (%) (n = 59 480)b | P Value | |
| Age at diagnosis, mean (SD), y | 74.3 (6.0) | 76.0 (6.0) | <.001 | 75.2 (6.4) | 75.2 (5.9) | .29 |
| Ethnicity | ||||||
| White | 69 053 (75.3) | 48 480 (77.8) | <.001 | 70 912 (78.1) | 45 656 (76.7) | .01 |
| African American | 10 286 (11.2) | 6385 (10.2) | 10 361 (11.1) | 6492 (10.9) | ||
| Hispanic | 5814 (6.3) | 3307 (5.3) | 5625 (6.8) | 3958 (6.7) | ||
| Other | 6606 (7.2) | 4158 (6.7) | 6341 (6.8) | 3958 (6.7) | ||
| Marital status | ||||||
| Married | 63 907 (69.7) | 41 324 (66.3) | <.001 | 63 127 (67.7) | 40 889 (68.8) | <.001 |
| Single, separated, or divorced | 27 852 (30.4) | 21 006 (33.7) | 30 111 (32.3) | 18 590 (31.3) | ||
| Geographic area | ||||||
| Metropolitan | 82 228 (89.6) | 51 919 (83.3) | .001 | 81 121 (87.0) | 51 008 (85.8) | <.001 |
| Urban | 8447 (9.2) | 9185 (14.7) | 10 772 (11.6) | 7410 (12.5) | ||
| Rural | 1084 (1.2) | 1226(1.9) | 1345 (1.4) | 1063 (1.8) | ||
| Charlson Comorbidity Index | ||||||
| 0 | 75 763 (82.6) | 42 344 (68.0) | <.001 | 70 713 (75.8) | 44 056 (74.1) | <.001 |
| 1-2 | 13 788 (15.0) | 17 529 (28.1) | 19 753 (26.8) | 13 213 (22.2) | ||
| >3 | 2208 (2.4) | 2457 (3.9) | 2772 (2.9) | 2211 (3.7) | ||
| Socioeconomic status | ||||||
| Low | 30 019 (33.5) | 23 536 (38.8) | <.001 | 32 398 (34.8) | 21 523 (36.2) | <.001 |
| Medium | 22 471 (25.1) | 14 741 (24.8) | 24 953 (26.8) | 16 075 (27.0) | ||
| High | 37 200 (41.5) | 22 445 (37.0) | 35 887 (38.5) | 21 881 (36.8) | ||
| Year of diagnosis | ||||||
| 1996 | 7769 (8.4) | 3839 (6.2) | <.001 | 7959 (8.5) | 5381 (9.1) | <.001 |
| 1997 | 7855 (8.6) | 4243 (6.8) | 7782 (8.4) | 4880 (8.2) | ||
| 1998 | 7747 (8.4) | 4380 (7.0) | 7675 (8.2) | 5049 (8.5) | ||
| 1999 | 8006 (8.7) | 4964 (7.9) | 7904 (8.5) | 4916 (8.3) | ||
| 2000 | 15 588 (17.0) | 11 073 (17.8) | 15 582 (16.7) | 10 253 (17.6) | ||
| 2001 | 15 576 (16.9) | 11 588 (18.6) | 15 530 (16.7) | 10 465 (17.6) | ||
| 2002 | 15 473 (16.9) | 11 725 (18.8) | 15 784 (16.9) | 10 135 (17.0) | ||
| 2003 | 13 815 (15.1) | 10 518 (16.9) | 15 022 (16.1) | 8401 (14.1) | ||
| Cancer grade | ||||||
| Well differentiated | 5644 (6.2) | 1953 (3.1) | <.001 | 4534 (4.9) | 2847 (4.8) | <.001 |
| Moderately differentiated | 62 265 (67.9) | 34 903 (56.0) | 57 270 (61.4) | 37 495 (63.0) | ||
| Poorly differentiated or undifferentiated | 16 310 (17.8) | 21 376 (34.3) | 23 629 (25.3) | 148 993 (25.1) | ||
| Unknown | 7540 (8.2) | 4098 (6.6) | 7805 (8.4) | 4239 (7.1) | ||
| Treatment | ||||||
| Surgery (monotherapy or multimodal therapy) | 24 188 (26.4) | 11 836 (18.9) | <.001 | 21 279 (22.8) | 14 089 (23.6) | <.001 |
| Radiation (monotherapy or multimodal therapy) | 39 353 (43.0) | 42 903 (68.8) | 50 032 (53.7) | 33 410 (56.2) | ||
| Chemotherapy (alone) | 243 (0.3) | 7327 (11.8) | 5111 (5.5) | 3061 (5.2) | ||
| No treatment | 27 975 (30.5) | 264 (0.4) | 16 815 (18.0) | 8919 (15.0) | ||
| Diagnosis in the 2-y period after prostate cancer diagnosis | ||||||
| Alzheimer disease | 8618 (9.4) | 8137 (13.1) | <.001 | 9073 (9.7) | 6406 (10.8) | <.001 |
| Dementia | 14 511 (15.8) | 13 463 (21.6) | <.001 | 15 602 (16.7) | 10 495 (17.6) | <.001 |
Abbreviation: ADT, androgen deprivation therapy.
a
Adjusted for age at diagnosis, race/ethnicity, geographic area, marital status, comorbidity score, cancer stage, and socioeconomic status.
b
Numbers are synthetic values derived from weights.