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Expression of NAPRT1 was analyzed in lymphoblastoid cell lines from 20 individuals (10 cases and 10 controls) of each rs10866912 genotype, including AA homozygous for risk allele, CA heterozygous, and CC homozygous for the protective allele. NAPRT1 expression shows a dose-response association with the rs10866912 genotype in these samples, with the A risk allele downregulating expression. P = .004 for AA vs CC.
