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. 2019 Jul 3;11:6043–6059. doi: 10.2147/CMAR.S197583

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© 2019 Chen et al.

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The schematic representation of LINC01116 in the progression of OSCC by regulating miR-136 and FN1. In OSCC cells, high expression of LINC01116 promotes the expression of FN1 through competitively binding to miR-136. Meanwhile, up-regulation of FN1 could promote the proliferation, EMT, and metastasis of OSCC cells, corresponding to inhibited the expression of E-cadherin and promoted the expression of Vimentin, N-cadherin, and MMP-9.

Abbreviations: OSCC, oral squamous cell carcinoma; miR-136, microRNA-136; FN1, fibronectin1; MMP-9, matrix metalloprotein 9; E-cadherin, epithelial cadherin; N-cadherin, neural cadherin; EMT, epithelial–mesenchymal transition.