TABLE 4.
ApoB, Cholesterol Levels, and Concordance/Discordance Between ApoB and Cholesterol Categories in Relation to Risk of Y25 CAC>0
| OR (95 % CI) | ||||
|---|---|---|---|---|
| Unadjusted | Model 1* | Model 2* | Model 3* | |
| ApoB† tertiles | ||||
| Low (referent) (n = 915) | 1.00 | 1.00 | 1.00 | 1.00 |
| Middle (n = 944) | 1.77‡ (1.41–2.21) | 1.62‡ (1.28–2.04) | 1.58‡ (1.24–2.00) | 1.53‡ (1.20–1.94) |
| High (n = 935) | 3.06‡ (2.47–3.80) | 2.81‡ (2.24–3.53) | 2.49‡ (1.97–3.15) | 2.28‡ (1.79–2.89) |
| LDL-C§ tertiles | ||||
| Low (referent) (n = 929) | 1.00 | 1.00 | 1.00 | 1.00 |
| Middle (n = 924) | 1.51‡ (1.22–1.88) | 1.45‡ (1.15–1.83) | 1.47‡ (1.16–1.86) | 1.41|| (1.11–1.80) |
| High (n = 941) | 2.65‡ (2.15–3.27) | 2.50‡ (2.00–3.12) | 2.37‡ (1.88–2.99) | 2.23‡ (1.77–2.82) |
| NHDL-C¶ tertiles | ||||
| Low (referent) (n = 923) | 1.00 | 1.00 | 1.00 | 1.00 |
| Middle (n = 927) | 1.62‡ (1.29–2.02) | 1.52‡ (1.20–1.92) | 1.47‡ (1.16–1.87) | 1.40† (1.10–1.78) |
| High (n =944) | 3.13‡ (2.53–3.88) | 2.79‡ (2.23–3.50) | 2.54‡ (2.01–3.22) | 2.32‡ (1.83–2.95) |
| ApoB/LDL-C | ||||
| Low/low (referent) (n = 1,153) | 1.00 | 1.00 | 1.00 | 1.00 |
| Low/high (n = 244) | 1.40# (1.01–1.93) | 1.30 (0.92–1.82) | 1.30 (0.92–1.85) | 1.29 (0.91–1.83) |
| High/low (n = 241) | 1.79‡ (1.31–2.44) | 1.89‡ (1.36–2.62) | 1.66|| (1.18–2.33) | 1.55|| (1.10–2.18) |
| High/high (n = 1,156) | 2.48‡ (2.06–3.00) | 2.30‡ (1.88–2.81) | 2.09‡ (1.70–2.57) | 1.94|| (1.58–2.40) |
| ApoB/NHDL-C | ||||
| Low/low (referent) (n = 1,184) | 1.00 | 1.00 | 1.00 | 1.00 |
| Low/high (n = 213) | 1.42# (1.01–1.99) | 1.30 (0.91–1.85) | 1.23 (0.85–1.77) | 1.19 (0.82–1.72) |
| High/low (n = 217) | 1.49# (1.06–2.08) | 1.63|| (1.15–2.32) | 1.51# (1.05–2.17) | 1.45# (1.01–2.09) |
| High/high (n = 1,180) | 2.53 (2.10–3.04) | 2.32‡ (1.91–2.83) | 2.07‡ (1.69–2.54) | 1.91|| (1.55–2.35) |
*
Model 1: adjusted for age, sex and race; Model 2: Model 1 + baseline (smoking status, systolic BP, antihypertensive medication use, diabetes, and BMI); Model 3: Model 2 + HDL-C and lipid-lowering medication use.
†
Median apoB: 88 g/dl.
‡
p < 0.001 compared with the referent group.
§
Median LDL-C: 107 mg/dl.
||
p < 0.01 compared with the referent group. Median NHDL-C: 121 mg/dl.
#
p < 0.5 compared with the referent group.
CI = confidence interval; OR = odds ratio; other abbreviations as in Table 1.