S3.

Partial list of differentially downregulated genes between HCT116-TP53(R273H) and HCT116-TP53(WT) cells

Gene accession	Gene symbol	Gene description	Fold change	P
NM_024915	GRHL2	grainyhead-like 2 (Drosophila)	9.25	0.0025
NM_004360	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	7.25	1.66E−04
NM_001034915	ESRP1	epithelial splicing regulatory protein 1	7.19	1.40E−04
NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)	6.63	0.0117
NM_020672	S100A14	S100 calcium binding protein A14	6.62	9.27E−04
NM_001624	AIM1	absent in melanoma 1	6.55	0.0036
NM_005603	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	6.00	2.02E−04
NM_005498	AP1M2	adaptor-related protein complex 1, mu 2 subunit	5.45	0.0178
NM_004949	DSC2	desmocollin 2	5.20	0.0090
NM_001012964	KLK6	kallikrein-related peptidase 6	5.14	0.0055