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. 2019 Jul 4;11:6201–6214. doi: 10.2147/CMAR.S197557

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© 2019 Zhang et al.

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Function of LincRNA-p21 in EC109 cells. The cell proliferation activity was evaluated using EdU-incorporation assays and CCk-8 assay. Cells labeled in red after reaction of EdU (5-ethynyl-2′-deoxyuridine) and Apollo represent proliferative cells., cell nuclei stained with Hoechst 33,342 (blue) represent the total cells (FSX100, 200× magnification), LincRNA-p21 reduced activity of EC109 (A and B). Apoptosis rate and each phase of cell cycle were analyzed by flow cytometry (C and D). (E) The metastatic and infiltrated potential of EC09 cells was evaluated using the migration and invasion assay in vitro. The results indicated a significant decline in cells to pass through the Matrigel membrane after LincRNA-p21-knockin relative to the untreated control. Data indicate mean ± SD, n=3. *P<0.05.