Table 6.
Seventeen significant pathways from KEGG enrichment analysis
| ID | Definition | Pathway name | Genea | DEGb | P-value |
|---|---|---|---|---|---|
| hsa05322 | Systemic lupus erythematosus | Autoimmune disease | 138 | 14 | 0.000 |
| hsa05330 | Allograft rejection | Alloimmune response | 39 | 7 | 0.000 |
| hsa04940 | Type I diabetes mellitus | Autoimmune disease | 45 | 7 | 0.000 |
| hsa04612 | Antigen processing and presentation | Immune system | 78 | 9 | 0.000 |
| hsa05332 | Graft-versus-host disease | Immune system | 43 | 6 | 0.001 |
| hsa05320 | Autoimmune thyroid disease | Autoimmune disease | 54 | 6 | 0.004 |
| hsa04650 | Natural killer cell mediated cytotoxicity | Immune system | 137 | 10 | 0.006 |
| hsa04060 | Cytokine-cytokine receptor interaction | Inflammatory defenses | 265 | 15 | 0.009 |
| hsa03050 | Proteasome | Immune responses, Stress, signaling, inflammatory | 45 | 5 | 0.009 |
| hsa04512 | ECM-receptor interaction | Tissue and organ morphogenesis | 85 | 7 | 0.011 |
| hsa04380 | Osteoclast differentiation | Immune receptors | 128 | 9 | 0.011 |
| hsa05416 | Viral myocarditis | Cardiac disease | 72 | 6 | 0.017 |
| hsa05166 | HTLV-I infection | Virus infection | 267 | 14 | 0.020 |
| hsa04145 | Phagosome | Inflammation and infectious | 155 | 9 | 0.033 |
| hsa03440 | Homologous recombination | Repair of DNA | 28 | 3 | 0.045 |
| hsa04115 | p53 signaling pathway | Signal transduction | 69 | 22 | 0.047 |
| hsa05323 | Rheumatoid arthritis | Alloimmune response | 92 | 6 | 0.048 |
Notes: aThe number of genes in the pathway. bThe number of genes differentially expressed.