Fig 2. The mechanistic model framework predicts observed gadoxetate levels in chronic liver disease.
(A, B) Observations and model-based predictions of gadoxetate levels, indicated by the changes in R1 relaxation rate (ΔR1, which is directly proportional to the gadoxetate concentration) in two patients, one with no fibrosis (F0) and one with histologically proven cirrhosis (F4). (C, E) The model is validated by predicting the gadoxetate concentration in blood and biopsy samples, which was acquired after the MRI examination. (D, F) Correlation between the measured and model-predicted gadolinium concentrations. The solid line is a linear regression and the dotted lines are 95% confidence intervals.