Comparison 1. Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Neonatal death (age < 28 days)	3	355	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.31, 0.91]
2 Infant death (age < one year)	5	1115	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.71, 1.13]
3 BPD (supplementary oxygen ar 36 weeks; PMA or death due to BPD)at 36 week's PMA	2	666	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.87, 1.14]
4 Bronchopulmonary dysplasia (at 28 to 30 days of age)	3	343	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.54, 1.13]
5 Bronchopulmonary dysplasia (at 36 to 38 weeks PMA)	2	737	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.90, 1.20]
6 Retinopathy of prematurity, stage ≥ 3 or ≥ 2	3	810	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.75, 1.06]
6.1 ROP ≥ 3	2	262	Risk Ratio (M‐H, Fixed, 95% CI)	0.09 [0.01, 0.67]
6.2 Retinopathy of prematurity, stage ≥ 2	1	548	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.80, 1.13]
7 Retinopathy of prematurity, any stage	4	889	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.83, 1.07]
8 Necrotizing enterocolitis (suspected or proven)	5	1115	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.64, 1.39]
9 Sepsis (early and/or late onset)	4	1067	Risk Ratio (M‐H, Fixed, 95% CI)	1.21 [0.95, 1.54]
10 Intraventricular haemorrhage, grade > 2	5	1103	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.58, 1.01]
11 Intraventricular haemorrhage, all grades	3	427	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.59, 1.00]
12 Minor neural developmental impairment at one year corrected age	1	169	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.38, 1.86]
13 Major neural developmental impairment at one year corrected age	1	169	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.24, 1.16]