Comparison 3. Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at < 30 weeks' PMA.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Type 1 ROP or death before determination of ROP outcome using the adjudicated ROP outcome	2	679	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.99, 1.67]
2 Type 1 ROP	1	511	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [0.89, 2.24]
3 Death before determination of ROP outcome	1	638	Risk Ratio (M‐H, Fixed, 95% CI)	1.53 [1.02, 2.31]
4 Type 1 ROP including adjudicated ROP outcome	2	605	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [0.82, 1.86]
5 Any ROP	1	553	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.88, 1.13]
6 ROP ≥ 2 ROP	1	548	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.80, 1.13]
7 All cause infant mortality to 55 week's PMA	1	638	Risk Ratio (M‐H, Fixed, 95% CI)	1.67 [1.12, 2.48]
8 All cause mortality (outcome collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth)	2	701	Risk Ratio (M‐H, Fixed, 95% CI)	1.35 [0.91, 2.00]
9 BPD (requiring oxygen at 36 week's PMA for oxygen saturation > 90%)	1	560	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.89, 1.18]
10 BPD or death by it prior to 37 weeks' PMA (outcomes collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth)	2	616	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.87, 1.16]
11 Severe IVH (grade 3 or 4)	2	690	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.65, 1.29]
12 Cystic areas in the cerebral parenchyma measured through 28 d	2	225	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.58, 2.85]
13 Early onset sepsis	1	63	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
14 Late onset sepsis (> 72 hrs of age)	2	701	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [1.00, 1.75]
15 Suspected or proven NEC	2	701	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.55, 1.41]
16 Surgical NEC	2	701	Risk Ratio (M‐H, Fixed, 95% CI)	1.21 [0.57, 2.58]
17 Spontaneous gastro‐intestinal perforation	2	701	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.48, 1.52]
18 Pulmonary haemorrhage	1	638	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.59, 1.62]
19 PDA	2	700	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.85, 1.14]
20 PDA requiring indomethacin	1	637	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.67, 1.22]
21 PDA requiring surgery	2	700	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.65, 1.42]
22 Seizure treatment for ≥ 2 days	2	700	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.43, 2.56]
23 Negative hearing screening in either ear at discharge	2	472	Risk Ratio (M‐H, Fixed, 95% CI)	1.45 [0.92, 2.29]
24 Respiratory distress syndrome	1	63	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.91, 1.09]
25 Sepsis, necrotizing enterocolitis, pneumonia or other infection as a cause of death	1	83	Risk Ratio (M‐H, Fixed, 95% CI)	1.36 [0.95, 1.93]