Table 2.

Incidence of subsequent demyelinating diseases of the central nervous system, rather than multiple sclerosis, stratified by severity of septicaemia

	N	Event	PYs	Rate	Crude HR (95% CI)	Adjusted HR (95% CI)
All
Comparison group	1 892 825	136	12 352 780	1.10	Reference group	Reference group
Septicaemia	482 781	144	2 082 900	6.91	5.99 (4.73 to 7.58)***	4.17 (3.21 to 5.4)***
Length of stay due to septicaemia*
Comparisons	1 892 825	136	12 352 780	1.10	Reference group	Reference group
1–5 days	91 289	16	523 515	3.06	2.73 (1.63 to 4.59)***	2.17 (1.27 to 3.69)***
>5 days	391 492	128	1 559 385	8.21	7.06 (5.54 to 9.01)***	4.73 (3.62 to 6.18)**
P for trend					<0.0001	<0.0001
Severity of septicaemia
Comparisons	1 892 825	136	12 352 780	1.10	Reference group	Reference group
Mild (T1)	144 548	14	1 115 282	1.26	1.12 (0.64 to 1.93)	0.83 (0.47 to 1.45)
Moderate (T2)	145 160	34	657 778	5.17	4.92 (3.36 to 7.19)***	3.35 (2.25 to 4.98)***
Severe (T3)	193 073	96	309 840	31.0	28.5 (21.4 to 38.0)***	18.7 (13.7 to 25.6)***
P for trend					<0.0001	<0.0001

Models adjusted for age, sex and comorbidities listed in table 1. Severity = (total length of hospital stay due to septicaemia during the follow-up duration) ÷ (length of follow-up duration). T1, the first tertile:<0.44%; T2, the second tertile: 0.44%–1.58%; T3 the third tertile:>1.58%.

**p<0.01; ***p<0.001.

*The first time hospitalisation due to septicaemia.

PYs, person-years;Rate, incidence rate, per 100 000 person-years.