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SAHA decreases late gene expression from clinically relevant HAdV serotypes. A549 cells were infected with HAdV-4 (A), HAdV-5 (B), or HAdV-7 (D) at an MOI of 10 and treated with the indicated concentrations of SAHA for 8 to 48 h. Fiber protein was detected in cell lysates by immunoblotting. (C and E) The 48-hpi samples from panels B and D were reanalyzed using shorter exposures in panels C and E, respectively, to illustrate the decrease in late gene expression more clearly.
