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Analysis of small- and large-plaque variants in the MACmut virus population. (A) MACmut isolates with distinct plaque sizes were evaluated for a ts phenotype. (B and C) Sequence analysis of individual plaque-purified revertant isolates identified mutations in the macrodomain and the adjacent downstream region in the large-plaque variants of the MACmut (B) and tsNC11 (C) viruses.
