TABLE 1.
Comparison of OPXV CP77 orthologs to CPXV BR CP77
| OPXV species | CP77 |
Antagonism to chSAMD9L | |
|---|---|---|---|
| Length (aa) | Identity (%) | ||
| CPXV | 661–674 | 91–100 | Yes |
| MPXV | 659–660 | 90–91 | Yes |
| VACV | Small deletions, early frameshift | No | |
| VARV | >60-nt deletion, 355–490 | 86–88 | NDa |
| ECTV | 504-nt deletion, early frameshift | No | |
| CMLV | Large deletion (∼155 nt remaining) | No | |
| TATV | 661 | 92 | Yes |
| AKMV | 672 | 79 | Yes |
| SKPV | 633 | 69 | Yes |
| VPXV | 613 | 69 | Yes |
| RNCV | Gene fusion,b 406 | 66 | Partial |
a
ND, not determined.
b
Strain MD1964-85A. aa 1 to 406 of the CP77 ortholog is fused in frame to the N terminus of the full-length, 246-aa chemokine binding protein; the total protein length is 655 aa.