FIG 2.

I-BET151 treatment shows no significant cytotoxicity in humanized mice. Animals were treated as described for Fig. 1, and cells harvested from spleen or bone marrow were counted and analyzed by flow cytometry. (A) Human CD45⁺ leukocyte numbers. (B) Human CD3⁺ T cell numbers. (C) CD3⁻ CD14⁻ CD11c⁺ dendritic cell numbers. (D) CD3⁻ CD11c⁺ CD14⁺ monocyte numbers. (E) Plots show percentages of CD4⁺ T cells and CD8 T cells in the spleen and bone marrow. (F) Summary data show percentages of CD4⁺ T cells and CD8 T cells in CD3⁺ cells in spleen and bone marrow. Bars in dot graphs indicate mean values.