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. Author manuscript; available in PMC: 2019 Jul 8.
Published in final edited form as: Cell Rep. 2019 Apr 2;27(1):11–19.e3. doi: 10.1016/j.celrep.2019.03.034

Figure 4.

Figure 4.

Cathepsin L Is Released by SFCs and Required for NC DNA Degradation (A–D) Stage 13 egg chambers of the indicated genotypes labeled with TUNEL (magenta, arrows) and DAPI (cyan).

(E) Quantification of TUNEL-positive NC nuclei in stage 13 egg chambers. ****p ≤ 0.0001.

(F–F”’) FC > mCD8-GFP, CP1-HA stage 13 egg chamber labeled with anti-HA (magenta) and DAPI (cyan). CP1-HA (magenta) is produced in the FCs (green, arrowhead) and released into the NCs (arrow).

(G–G”’) FC>CP1-HA egg chambers labeled with LT (magenta) and DAPI (cyan). CP1 is detected within LT-positive NCs (arrows) and not LT-negative NCs (arrowhead). Scale bars, 50 μm.