Fig. 1.

Study flow diagram and summary of 12-week outcomes in the study cohort. A. CONSORT diagram. B. Swimmers plot for the entire study cohort summarizing length of therapy, reason for treatment discontinuation, and disease-related deaths occurring before 12 weeks. C. Number of patients who discontinue therapy secondary to asymptomatic (radiographic) or symptomatic disease progression at or before 8 and 12 weeks. D. Top reasons for discontinuation due to clinical progression before 12 weeks. E. Clinical disease progression in the setting of baseline bulky disease. Baseline CT scan demonstrates bulky disease with 8 × 3 cm metastatic implant along the lesser curvature of the stomach. A CT scan at approximately 6 weeks of treatment demonstrated disease progression resulting in small bowel obstruction. SBO: small bowel obstruction.