Fig. 2.

Pre-treatment clinical parameters can predict early and very early treatment discontinuation. The receiver-operating characteristic (ROC) curves were used to plot the sensitivity along the y-axis and the “1-specificity” along the x-axis for comparing the multivariate model prediction versus the true binary outcome for both: A. 12-week (bulky disease and liver metastases), and B. 8-week (NLR and liver metastases) variables. The area under the ROC curve (AUC) is a measure of predictive accuracy where a value of 1 corresponds to a perfect prediction and a value of 0.5 to a totally random prediction.