. Author manuscript; available in PMC: 2020 Aug 1.

Published in final edited form as: J Diabetes Complications. 2019 May 17;33(8):547–549. doi: 10.1016/j.jdiacomp.2019.05.007

Table 2.

Pearson Correlation and Multivariable Linear Regression Models

Multivariable linear regression models		Adults with Longstanding Type 1 Diabetes
Multivariable linear regression models		GFR	ERPF	RVR	P_GLO	R_A	R_E	NGAL^a	β2M^a
NO	r (R²)	−0.08 (<1%), p=0.60	−0.04 (<1%), p=0.77	0.10 (1%), p=0.47	−0.02 (<1%), p=0.91	0.11 (1%), p=0.45	0.03 (<1%), p=0.83	0.07 (<1%), p=0.64	0.001 (<1%) p=0.99
NO	β±SE^b	−0.1±0.1, p=0.51	−0.3±0.6, p=0.64	0.2±0.2, P=0.31	−0.02±0.03, p=0.54	11.5±9.4, p=0.23	0.9±3.4, p=0.79	0.00±0.00, p=0.60	−0.00±0.00, p=0.60
cGMP^a	r (R²)	−0.01 (<0.1%), p=0.92	−0.38 (14%), p=0.004	0.38 (14%), p=0.005	0.01 (<0.1%), p=0.94	0.22 (5%), p=0.11	0.52 (27%), p<0.0001	0.49 (24%), p=0.0002	0.49 (24%), p=0.0002
cGMP^a	β±SE^b	4.2±5.2, p=0.42	−41.3±24.8, p=0.10	13.7±8.4, p=0.11	0.7±1.2, p=0.54	181.4±413.1, p=0.66	461.2±144.5, p=0.003	0.6±0.1, p<0.0001	0.6±0.1, p<0.0001

Natural log-transformed.

Adjusted for age, sex, SBP and HbA1c. β-estimates represent the change in the dependent variable per a 1-unit change in the independent variable.

GFR = glomerular filtration rate, ERPF = effective renal plasma flow, RVR = renal vascular resistance, P_GLO = glomerular pressure, R_A = afferent arteriolar tone, R_E = efferent arteriolar tone, NGAL = neutrophil gelatinase-associated lipocalin (NGAL) and B2M = β2-microglobulin.