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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Cell Neurosci. 2019 Jun 16;98:109–120. doi: 10.1016/j.mcn.2019.06.009

Figure 4: Mechanisms of mitochondrial quality control are interconnected with mechanisms of mitochondrial dynamics.

Figure 4:

Dysfunctional mitochondria are transported in the retrograde direction from distal sites to the cell body for degradation and recycling by lysosomes via mechanism called mitophagy. The PINK1/ PARKIN proteins are involved in targeting mitochondria for mitophagy. Autophagosomes that are converted to amphisomes are transported by dynein-snapin motor complexes along microtubules to the cell body for lysosomal degradation. In AD, Aβ can interfere with the formation of these complexes leading to the accumulation of dysfunctional mitochondria and subsequent axonal swelling.