Table 1.
Demographics and clinical characteristics of colorectal cancer patients and controls1
| Discovery stage: ColoCare Study | Replication stage: CORSA | ||||
|---|---|---|---|---|---|
| CRC patients | Controls | CRC patients | Controls | ||
| Number of participants | 180 | 153 | 88 | 200 | |
| Sex* ‡ | Men n(%) | 114 (63.3) | 59 (38.6) | 60 (68.2) | 130 (65.0) |
| Age* ¥ ‡ | Median (IQR) | 66.0 (58.0–73.0) | 51.0 (42.0–63.0) | 70.0 (60.0–76.0) | 64.0 (57.0–74.0) |
| Body mass index2 ,*,‡ (kg/m2) | Median (IQR) | 26.4 (24.1–29.2) | 23.5 (22.0–26.7) | 26.1 (23.8–29.4) | 27.0 (24.9–30.1) |
| Underweight, <18.5 n(%) | 2 (1.1) | 19 (12.4) | 0 (0) | 2 (1.0) | |
| Normal weight, 18.5–24.9 n(%) | 59 (32.8) | 3 (2.0) | 26 (29.5) | 47 (23.5) | |
| Overweight, 25–29.9 n(%) | 82 (45.6) | 91 (59.5) | 38 (43.2) | 94 (47.0) | |
| Obese, ≥30 n(%) | 37 (20.6) | 35 (22.9) | 15 (17.0) | 50 (25.0) | |
| Smoking status* n(%) | Current | 30 (16.6) | 25 (16.3) | 20 (22.7) | 25 (12.5) |
| Former | 77 (42.8) | 47 (30.7) | 30 (34.2) | 64 (32.0) | |
| Never | 61 (33.9) | 75 (49.1) | 35 (39.7) | 104 (52.0) | |
| Unknown | 12 (6.7) | 6 (3.9) | 3 (3.4) | 7 (3.5) | |
| Stage3 ,† n(%) | 0 | 7 (3.9) | ‐ | 0 (0) | ‐ |
| I | 34 (18.9) | ‐ | 30 (34.1) | ‐ | |
| II | 66 (36.7) | ‐ | 17 (19.3) | ‐ | |
| III | 47 (26.1) | ‐ | 18 (20.5) | ‐ | |
| IV | 25 (13.9) | ‐ | 12 (13.6) | ‐ | |
| Unspecified | 1 (0.5) | ‐ | 3 (3.4) | ‐ | |
| Unknown | 0 (0) | ‐ | 8 (9.1) | ‐ | |
| Tumor location4 ,† n(%) | Colon – distal | 53 (29.4) | ‐ | 21 (31.8) | ‐ |
| Colon – proximal | 57 (31.7) | ‐ | 33 (28.4) | ‐ | |
| Rectum | 70 (38.9) | ‐ | 34 (39.8) | ‐ | |
1
Controls are defined as individuals not diagnosed with any colorectal malignancy.
2
Missing BMI for n = 5, 9 and 7 for ColoCare controls, CORSA CRC patients and controls, respectively.
3
TNM for colorectal cancer with neo‐adjuvant therapy and colon cancers without surgery (28.7%), else pTNM was used (71.3%).
4
Distal colon: sigmoid colon, descending colon, splenic flexure; Proximal colon: transverse colon, hepatic flexure, ascending colon, cecum, appendix; Rectum: rectum, rectosigmoid junction.
¥
p‐value <0.05 between ColoCare and CORSA CRC.
†
p‐value <0.05 between CRC.
‡
p‐value <0.05 between controls.
*
p‐value <0.05 between ColoCare and CORSA controls.