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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Expert Opin Ther Targets. 2019 Jan 15;23(12):1041–1051. doi: 10.1080/14728222.2019.1565658

Figure 2.

Figure 2.

Senescence-associated secretory phenotype (SASP)-mediated immune cell recruitment aiding in tumor clearance. Both the innate and adaptive immune systems have been described to aid in SASP-mediated tumor clearance. (A) Various SASP factors recruit natural killer (NK) cells, macrophages, and neutrophils to the site of tissue damage, resulting in the clearance of both senescent and cancerous cells. (B) Various SASP factors recruit macrophages and monocytes, as well as cytotoxic CD4+ T cells. Macrophages and monocytes can activate these T cells, which then kill senescent and cancer cells.