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. 2018 Dec 11;21(7):1576–1584. doi: 10.1038/s41436-018-0375-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Frequency of the 51 selected candidate genes in current commercial test panels. All genes listed in the Genomics England hypertrophic cardiomyopathy (HCM) panel that were not in the Oxford Medical Genetics Laboratory (OMGL) clinical HCM test panel at the time of this study were selected for analysis. The bar chart displays the number of times each of the 51 selected candidate genes was included in a commercial test panel. Data was extracted from the National Center for Biotechnology Information (NCBI) Gene Tests website (October 2016) and Genetic Test Registry (December 2017). This included 10 clinical HCM panels and 11 clinical cardiomyopathy panels. Information on laboratories and available test panels is in Table S5. The gene labels are colored according to the review status as annotated by Genomics England, which gives an indication of the level of evidence supporting each gene–disease relationship: Green = high evidence, the gene is very likely be the cause of the disease and can be reported back to patients. Amber = moderate evidence, and should not yet be used for genome interpretation. Red = low evidence for a role in disease, or not suitable for clinical diagnosis at this time.