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. 2018 Dec 11;21(7):1576–1584. doi: 10.1038/s41436-018-0375-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Odds ratios with 95% confidence interval (CI) in hypertrophic cardiomyopathy (HCM) cases (n=240) compared with National Institute for Health Research Bioresource Rare Disease HCM project (BRRD) controls (n=6229). All = all rare variants. Nontruncating = missense, in-frame insertions and deletions, and other variants annotated as MODERATE impact by SNPEff. . Truncating = variants predicted to result in a truncated transcript (nonsense, frameshift, canonical splice site). Rare is defined as gnomAD minor allele frequency (MAF) <0.0001. Data plotted using log10 scale. Genes in which no rare variants were detected in cases have not been plotted. A single truncating variant in TCAP was found in cases and no truncating variants were detected in controls; this result is not significant when corrected for multiple testing.