Fig. 3. Memantine ameliorated spatial learning and memory deficits in AD mice assessed by the Morris water maze (MWM) test. (A) The escape latency of mice in training session from day 1 to day 5. (B) The swimming trajectory of mice during the probe test. (C) The latency to cross platform location (the platform was removed) during probe test. (D) Number of platform site crossovers in target quadrant during probe test. Bar graphs show mean±SEM, n=13,^*p<0.05 or ^**p<0.01 vs. WT group, ^#p<0.05 vs. AD group by two-tailed unpaired Student's t-test (ANOVA).