Table 2.
Rheological parameters for OA-PL407 and OA-PL188 in the absence (−) and presence (+) of simulated vaginal fluid (SVF).
| Simulated vaginal fluid (SVF) | Formulation | Additives | T (sol-gel) °C | 25 °C |
37 °C |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G' (Pa) | G'' (Pa) | G'/G'' | η* (mPas.s) x 10³ | G' (Pa) | G'' (Pa) | G'/G'' | η* (mPas.s) x 10³ | |||||
| (−) | PL 188 | 15% | – | Nd | 0.16 | 0.04 | 4 | 0.02 | 0.16 | 0.03 | 5.3 | 0.02 |
| VRC | Nd | 0.16 | 0.06 | 2.6 | 0.02 | 0.16 | 0.05 | 3.2 | 0.02 | |||
| 30% | – | 39.6 ± 0.9 | 0.17 | 0.31 | 0.5 | 0.05 | 2.1 | 13.2 | 0.2 | 2.1 | ||
| VRC | 39.4 ± 0.8 | 0.17 | 0.39 | 0.4 | 0.07 | 5.7 | 28.8 | 0.2 | 4.3 | |||
| PL 407 | 30% | – | <8 | 6784 | 784 | 8.7 | 1087 | 6429 | 712 | 9 | 1027 | |
| VRC | <8 | 14800 | 385 | 38.5 | 2356 | 13760 | 555 | 25 | 2191 | |||
| (+) | PL 188 | 15% | – | Nd | 0.03 | 5.4 | 0.005 | 23.9 | 0.02 | 7.8 | 0.003 | 0.02 |
| VRC | Nd | 0.03 | 4.3 | 0.007 | 23.3 | 0.02 | 6.1 | 0.003 | 0.02 | |||
| 30% | – | 39.7 ± 0.7 | 0.2 | 0.2 | 1 | 0.04 | 1.5 | 8.9 | 0.16 | 1.4 | ||
| VRC | 39.2 ± 0.6 | 0.2 | 0.2 | 1 | 0.03 | 0.8 | 5.4 | 0.14 | 0.9 | |||
| PL 407 | 30% | – | <8 | 13480 | 350 | 38.5 | 2147 | 12240 | 420.5 | 29.1 | 1948 | |
| VRC | <8 | 9210 | 244 | 37.7 | 1466 | 8177 | 264 | 30.9 | 1302 | |||
Note: The values refer to the G′ (elastic) and G″ (viscous) moduli, and viscosity (η), at 25 and 37 °C, and the sol-gel transition temperatures (Tsol-gel).