Table 3.
Drug release constants and correlation coefficients obtained for organogel formulations.
Formulation | Higuchi |
Zero order |
Hixson-Crowell |
Korsmeyer-Peppas |
||||||
---|---|---|---|---|---|---|---|---|---|---|
R2 | K0 (%.h−1/2) | R2 | K0 (%.h−1) | R2 | KHC (%.h−1/3) | R2 | KKP (%.h−n) | n | ||
PL407 | 30% | 0.96 | 7.8 ± 0.4 | 0.90 | 1.3 ± 0.1 | 0.79 | 0.05 ± 0.01 | 0.91 | 10.1 ± 1 | 0.4 ± 0.03 |
PL188 | 15% | 0.03 | 0.99 ± 1.2 | 0.06 | 0.3 ± 0.3 | 0.06 | 0.01 ± 0.01 | 0.006 | 64 ± 1 | 0.01 ± 0.02 |
30% | 0,96 | 7,8 ± 0,4 | 0,98 | 2.7 ± 01 | 0.91 | 0.1 ± 0.01 | 0.90 | 6.1 ± 1 | 0.68 ± 0.06 |
Data presented as mean ± S.D. (n = 3/formulation).