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. 2019 May 30;15(6):394–401. doi: 10.6026/97320630015394

Table 4. Evaluation of drug-like properties of the lead molecules by Qikprop Maestro 10.5 molecular docking suite.

Molecule QPlogPo/w (-2.0 to 6.5) Q P log HERG (acceptable range: above -5.0) QPP Caco (nm/s) <25 - poor >500 - great Q P log BB (-3 to 1.2) QPP MDCK (nm/s) Q Plog Kp (-8.0 to -0.1)
STOCK1N-98943 5.344 -6.281 46.395 -2.886 49.729 -3.431
STOCK1N-98872 3.653 -4.349 49.867 -2.486 35.846 -3.979
STOCK1N-98956 5.335 -5.366 141.335 -1.887 108.881 -0.2687
STOCK1N-98865 2.971 -2.726 23.795 -1.679 18.639 -4.377
STOCK1N-98950 2.358 -6.184 97.867 -1.871 39.817 -3.967