Table 2.
Catalog of FANTOM5 promoters in loci associated to hereditary neurodegenerative diseases. For each gene (gene symbol), the total number of robust TSSs (TSS DPI robust) and CAT clusters (CAT CAGE cluster robust) is indicated. The total number of promoters identified in this study is also shown (at the bottom)
| Disease | Gene symbol | TSS DPI robust | CAT CAGE cluster robust |
|---|---|---|---|
| AD | APP | 12 | 5 |
| AD | PSEN1 | 5 | 2 |
| AD | PSEN2 | 1 | 0 |
| FTD | C9orf72 | 4 | 1 |
| FTD | GRN | 0 | 0 |
| FTD | MAPT | 8 | 6 |
| PD | SNCA | 10 | 8 |
| PD | PRKN | 12 | 6 |
| PD | PINK1 | 2 | 6 |
| PD | PARK7 | 2 | 0 |
| PD | LRRK2 | 4 | 4 |
| PD | VPS35 | 0 | 1 |
| ALS | SOD1 | 2 | 6 |
| ALS | FUS | 0 | 6 |
| ALS | TARDBP | 0 | 2 |
| ALS | UBQLN2 | 1 | 2 |
| HD | HTT | 0 | 1 |
| Total | 63 | 56 |