Table 2.
The effects of prenatal stress (PS) and chronic antidepressant drugs treatment (tianeptine (Tia), venlafaxine (Ven), or fluoxetine (Flu)) on the immobility, mobility, and climbing time (in seconds) in the forced swim test and the number of visits and the time spent in the open arms of the elevated plus-maze
| Control | PS | Control + Tia | PS + Tia | Control + Ven | PS + Ven | Control + Flu | PS + Flu | |
|---|---|---|---|---|---|---|---|---|
| Forced swim test (FST, Porsolt test) | ||||||||
| Immobility (s) | 201 ± 4.8 | 275.16 ± 1.4* | 181.33 ± 8.02 | 229.56 ± 2.93# | 221.5 ± 8.32 | 229.56 ± 8.27# | 218 ± 7.22 | 248.8 ± 1.28# |
| Swimming (s) | 99 ± 4.8 | 24.83 ± 1.4* | 118.66 ± 8.02 | 70.33 ± 0.04# | 78.5 ± 8.32 | 70.33 ± 8.27# | 82 ± 7.22 | 51.2 ± 1.28# |
| Climbing (s) | 51.5 ± 3.37 | 16.16 ± 0.74* | 49.66 ± 4.72 | 35.66 ± 0.88# | 73.3 ± 8.47 | 50.66 ± 11.24 | 64.6 ± 3.33 | 25 ± 3.11 |
| Elevated plus-maze | ||||||||
| Number of visit in the open arms | 2.00 ± 0.44 | 0.33 ± 0.23* | 1.75 ± 0.42 | 3.2 ± 0.86# | 2.20 ± 0.58 | 3.66 ± 0.73# | 0.80 ± 0.49 | 0.40 ± 0.6 |
| Time spent in the open arm (s) | 17.00 ± 3.88 | 1.33 ± 1.46* | 10.75 ± 1.23 | 49.25 ± 9.72# | 20.16 ± 9.69 | 49.80 ± 9.54# | 12.6 ± 7.75 | 13.20 ± 3.97 |
The data are presented as the means ± SEMs, with n = 5–6 for each group
∗p ≤ 0.05 vs. control Veh group; #p ≤ 0.05 vs. prenatally stressed Veh group. ANOVA (two-way), followed by Duncan’s test